Journal of International Psychiatry

Objective To explore the correlation among post-stroke sleep disorders（PSSD）、lesion location and inflammatory factor.Methods 121 PSSD patients treated in our hospital were employed as PSSD group by random number table method from February 2018 to February 2019，and 125 stroke patients without PSSD were employed as normal group.The clinical data、the levels of cell factor[tumor necrosis factor -α（TNF-α）、interleukin-6（IL-6）and interleukin-1β（IL-1β）]and lesion location were comparatively analyzed,and analysing the correlative factor of PSSD. Result There was statistical difference in lesion location of stroke between two groups（P<0.05）；the level of TNF-α in the PSSD group was lower than that in the normal group，and the levels of IL-6 and IL-1β in the PSSD group were higher than those in the normal group（P<0.05）.Logistic regression analysis showed that the levels of TNF-α（OR=0.696，P=0.000）was the protective factor of PSSD；subcortical stroke lesions（OR=11.766，P=0.000），cortical stroke lesions（OR=5.037，P=0.001），the levels of IL-6（OR=1.289，P=0.000）、IL-1β（OR=1.451，P=0.000）were the risk factors of PSSD. There were statistical difference in the levels of TNF-α、IL-6 and IL-1β of patients with varying degrees of PSSD（P<0.05）；the level of TNF-α in the severe group was lower than that in the moderate group（P<0.017），and the level of TNF-α in the moderate group was lower than that in the mild group（P<0.017）；the levels of IL-6 and IL-1β in the severe group were higher than that in the moderate group（P<0.017），and the levels of IL-6 and IL-1βin the moderate group were higher than that in the mild group（P<0.017）.Conclusion The levels of TNF-α、IL-6、IL-1βand lesion location were obvious related to post-stroke sleep disorders，lesion location plays a important role in indicating patients’ PSSD occuring in clinical work，intervening the levels of cell factor may have clinical significance in improving the degree of sleep disorders.

Post-stroke sleep disorders;TNF-α;Interleukin;Cell factor