Journal of International Psychiatry

The cause of Depression is convoluted，the mutual relationship between environmental factors and genetic factors affect the development and progress of Depression. The effect triggered by early age pressure is deeply correlated with density，form and duration. Life on a start is in a crucial stage where cognitive and behavioral patterns establish, then grow gradually. With the research of clinical epidemiology, the majority of adolescents who develop a Depression are connected with an experience that they are under the pressure in the past. Maternal Separation（MS）is the most classical model about animals those who feel the stress in early life. This review primarily analyzes the relationship between MS and Depression, formulating a MS-Depression mechanism by a model with rodents and two aspects of epigenetics and neural endocrinology.

Maternal Separation、Depression、Epigenetics、Neuroendocrinology