Journal of International Psychiatry

Objective To investigate the differences of clinical features and clinical curative efficacy of modified electric convulsive therapy (MECT) between unipolar and bipolar major depression. Methods Retrospectively extracted the medical records of hospitalized patients from June 2015 to June 2018 in Oriental hospital affiliated to Xuzhou medical university. A total of 250 patients with unipolar major depression (unipolar group) and 92 patients with bipolar major depressive disorder (bipolar group) were included in our study. We contrastly analysis general information and evaluate clinical symptoms and clinical curative effect differences of MECT with Hamilton depression rating scale (HAMD - 17) total score points, five factors points and ratio of points for unipolar and bipolar major depression. Results The cure rate for bipolar group was significantly higher than unipolar group（P＜0.01). Bipolar group of HAMD-17 ratio of points is superior to unipolar group, with significant statistical differences (P < 0.01). The ratio of points for unipolar group of retardation factor points was higher than bipolar group , however bipolar group of somatic anxiety factor points is higher than unipolar group , with significant statistical differences (P < 0.01) . Both the average numberand total number of MECT for bipolar groupwere higher than in unipolar group, the difference has statistical significance (P < 0.01) . Conclusion (1). Compared with unipolar major depression, bipolar major depression patients with earlier onset age, younger treatment, higher educational level, family history of higher positive rate, longer duration, and heavier retardation symptom. (2). The pathogenesis of bipolar and unipolar major depression were different, and may also prompt that MECT is more suitable for retardation Symptoms of unipolar major depression and somatic anxiety symptoms of bipolar major depression. (3). The significant clinical curative effect of MECT treatment is distinct for both unipolar and bipolar major depression. Compared with unipolar major depression, MECT treatment for bipolar major depression work slower, treatment duration is longer, but clinical curative effect is better.

Bipolar major depression；Unipolar major depression；Modified electric convulsive therapy ；Clinical characteristics ; Clinical efficacy