| Abstract |
Objective: To detect the levels of LNC RNA BDNF-AS and GOMAFU in plasma of patients with bipolar affective disorder and to explore their clinical significances. Methods From September 2016 to September 2018, 112 patients with bipolar affective disorder (58 in manic group, 54 in depression group), 46 patients with schizophrenia, and 45 healthy physical examiners were selected as subjects, the levels of plasma LNC RNA, BDNF-AS, brain-derived neurotrophic factor (BDNF), and GOMAFU were measured by qRT-PCR, Young Mania Rating Scale (YMRS) and Hamilton Depression Scale (HAMD) were used to assess the mania and depression of patients with bipolar affective disorder. Pearson was used to analyze the correlations between levels of plasma LNC RNA, BDNF-AS, GOMAFU with symptoms in manic and depressive patients. Results Compared with the control group, the level of plasma BDNF-AS in schizophrenia group and bipolar affective disorder group increased significantly (P < 0.05), while the levels of BDNF and GOMAFU decreased significantly (P < 0.05); compared with schizophrenia group, the level of plasma BDNF-AS in bipolar affective disorder group increased significantly (P < 0.05), while the levels of plasma BDNF and GOMAFU were significantly decreased (P < 0.05); the area under the curve of plasma BDNF-AS level in the diagnosis of bipolar affective disorder was 0.843, the diagnostic threshold was 6.75, the sensitivity was 79.83%, and the specificity was 79.76%, the area under the curve of plasma GOMAFU level in the diagnosis of bipolar affective disorder was 0.736, the diagnostic threshold was 0.68, the sensitivity was 95.56%, and the specificity was 57.26%; compared with the control group, the level of plasma BDNF-AS in manic group and depression group increased significantly (P < 0.05), and the levels of BDNF and GOMAFU decreased significantly (P < 0.05), compared with depression group, the level of plasma BDNF-AS in manic group increased significantly (P < 0.05), while the levels of BDNF and GOMAFU decreased significantly (P < 0.05); Pearson correlation analysis showed that there was no significant correlation between plasma BDNF-AS, GOMAFU levels with YMRS score in manic patients (P > 0.05), and there was no significant correlation between plasma BDNF-AS, GOMAFU levels with HAMD score in depressive patients (P > 0.05). Conclusion The level of plasma LNC RNA BDNF-AS in patients with bipolar affective disorder is up-regulated, GOMAFU level is down-regulated, both of them may serve as potential indicators for clinical diagnosis of bipolar affective disorder.
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