卡左双多巴控释片联合多巴丝肼片对帕金森患者认知功能与血清因子水平的影响
Effect of Kazuo Double Dopa Controlled Release Tablets Combined with Dopass Tablet on Cognitive Function and Serum Factor Levels in Parkinsons Patients
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(3) |
| 作者 |
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| 作者单位 |
安阳市第三人民医院 ;
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| 摘要 |
分析帕金森患者应用卡左双多巴控释片联合多巴丝肼片治疗后临床疗效及认知功能变化。方法 将我院97例帕金森患者采用随机数字表法分组，对照组48例给予多巴丝肼片口服，观察组49例联合卡左双多巴控释片口服，对比两组患者治疗后认知功能、精神状态、多巴胺(DA)、去甲肾上腺素(NE)、５-羟色胺(5-HT)、血清脑源性神经营养因子(BDNF)水平变化、临床疗效及不良事件发生率。结果 观察组治疗后5-HT、BDNF、NE、DA水平、MoCA、MMSE评分及总有效率均高于对照组，UPDRES评分低于对照组（P<0.05）；不良事件发生率低于对照组（P>0.05）。结论 卡左双多巴控释片联合多巴丝肼片有效改善帕金森患者认知功能及精神状态，其机制与提升多巴胺水平，调节5-HT、BDNF、NE水平有关。
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| Abstract |
Objective To analyze the clinical efficacy and cognitive function of patients with Parkinsons disease treated with Kazuo Shuangdoba controlled release tablets combined with Dopas. Methods 97 patients with Parkinsons disease in our hospital were randomly assigned to a random number table. 48 patients in the control group were given oral administration of dopas-salt tablets, and 49 patients in the observation group were given oral administration of carbazide-dopa control tablets. Known function, mental state, dopamine (DA), norepinephrine (NE), serotonin (5-HT), serum brain-derived neurotrophic factor (BDNF) levels, clinical efficacy and incidence of adverse events. Results The levels of 5-HT, BDNF, NE, DA, MoCA, MMSE and total effective rate in the observation group were higher than those in the control group, and the UPDRES score was lower than that in the control group (P<0.05). The incidence of adverse events was lower than that in the control group.(P>0.05). Conclusion Cardiodide-dopa controlled-release tablets combined with dopas-suppressive tablets can effectively improve the cognitive function and mental state of Parkinsons patients. The mechanism is related to the increase of dopamine levels and the regulation of 5-HT, BDNF and NE levels.
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| 关键词 |
卡左双多巴控释片；多巴丝肼片；帕金森；认知功能；血清因子
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| KeyWord |
Kazuo double dopa controlled release tablets; dopas sputum; Parkinson; cognitive function; serum factor
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| 基金项目 |
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| 页码 |
496-498 |
樊润润*.
卡左双多巴控释片联合多巴丝肼片对帕金森患者认知功能与血清因子水平的影响 [J].
国际精神病学杂志.
2019; 46; (3).
496 - 498.