拉莫三嗪应用于脑外伤术后患者效果及对认知功能与癫痫的影响分析
Effect of lamotrigine on postoperative patients with traumatic brain injury and its influence on cognitive function and epilepsy
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(3) |
| 作者 |
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| 作者单位 |
安阳市第二人民医院神经外科 ;
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| 摘要 |
分析脑外伤术后患者应用拉莫三嗪治疗后认知功能变化及对癫痫发生率的影响。方法 采用随机数字表法将我院119例重症颅脑外伤患者分组，两组患者均给予开颅减压术治疗，对照组59例术前给予丙戊酸钠口服，术后持续口服30d，观察组60例给予拉莫三嗪口服，服用方法同对照组，对比两组患者术后癫痫发生率、认知功能变化及不良事件发生率。结果 观察组早期、晚期癫痫发生率及不良事件发生率均低于对照组，术后1月、3月、6月MMSE评分均高于对照组（P<0.05）。结论 拉莫三嗪能够有效减少重症颅脑损伤术后患者癫痫发作，改善认知功能，安全性高。
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| Abstract |
Objective To analyze the changes of cognitive function and the incidence of epilepsy after treatment with lamotrigine in patients with traumatic brain injury. Methods A total of 119 patients with severe craniocerebral trauma were randomly divided into two groups. The patients in the control group were treated with craniotomy decompression. 59 patients in the control group were given sodium valproate orally for 30 days. 60 patients in the group were given lamotrigine orally. The method of administration was the same as that of the control group. The incidence of epilepsy, cognitive function and incidence of adverse events were compared between the two groups. Results The incidence of early and late epilepsy and adverse events in the observation group were lower than those in the control group. The MMSE scores in the first, third and sixth months were higher than those in the control group (P<0.05). Conclusion Lamotrigine can effectively reduce seizures, improve cognitive function and safety in patients with severe craniocerebral injury.
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| 关键词 |
拉莫三嗪；丙戊酸钠；脑外伤；认知功能；癫痫
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| KeyWord |
lamotrigine; sodium valproate; brain trauma; cognitive function; epilepsy
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| 基金项目 |
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| 页码 |
515-517 |
何源*.
拉莫三嗪应用于脑外伤术后患者效果及对认知功能与癫痫的影响分析 [J].
国际精神病学杂志.
2019; 46; (3).
515 - 517.