Journal of International Psychiatry

Objective To analysis of liver ultrasound characteristics and related factors in patients taking long-term olanzapine.Methods A retrospective analysis of 152 patients with schizophrenia treated in our hospital from June 2016 to February 2019 was conducted. The time of taking olanzapine was divided into short-term group (Continuous medication≤6 months)and long-term group(Continuous medication≥2 years), 76 cases in each group.To compare the characteristics of liver ultrasound in the two groups, and to analyze the influencing factors of liver ultrasound characteristics by univariate and multivariate logistic regression models.Resules The incidence of gallbladder stones, intrahepatic bile duct stones and fatty liver in the long-term group was significantly higher than that in the short-term group, but there was no significant difference in the incidence of cholecystitis and diffuse liver injury between the two groups (P>0.05).Univariate logistic regression analysis showed that gallstones, intrahepatic bile duct stones, and fatty liver were related factors of liver ultrasound abnormalities, but there was no significant correlation between cholecystitis, diffuse liver damage and liver ultrasound abnormalities.Multivariate logistic regression analysis showed that gallstones, intrahepatic bile duct stones, and fatty liver were independent risk factors for liver ultrasound abnormalities.Conclusion Long-term use of olanzapine may lead to drug-induced liver damage in patients, and gallstones, intrahepatic bile duct stones, and fatty liver are independent risk factors for liver ultrasound abnormalities.

Olanzapine; Ultrasound characteristics of liver; Schizophrenia; Related factors analysis