帕利哌酮联合丙戊酸钠治疗脑外伤所致精神障碍攻击行为的临床有效性和安全性
Clinical efficacy and safety of paliperidone combined with sodium valproate in the treatment of mental disorder aggressive behavior caused by brain trauma
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(3) |
| 作者 |
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| 作者单位 |
天津市安定医院普通精神科七科 ;
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| 摘要 |
目的：探讨帕利哌酮联合丙戊酸钠治疗脑外伤所致精神障碍攻击行为的临床有效性和安全性。方法：随机选取2016年8月至2018年8月我院脑外伤所致精神障碍攻击行为患者60例，随机分为2组：一组帕利哌酮联合丙戊酸钠治疗组（联合治疗组，30例），一组帕利哌酮单独治疗组（单独治疗组，30例），统计分析两组患者的MOAS评分、临床疗效、服药期间不良反应发生情况。结果：两组患者治疗后的MOAS评分均显著低于治疗前（P<0.05）；治疗前两组患者的MOAS评分之间的差异不显著（P>0.05），治疗后联合治疗组患者的MOAS评分显著低于单独治疗组（P<0.05）。联合治疗组患者治疗的总有效率90.0%（27/30）显著高于单独治疗组73.3%（22/30）（P<0.05）。两组患者服药期间的不良反应发生率20.0%（6/30）、23.3%（7/30）之间的差异不显著（P>0.05）。结论：帕利哌酮联合丙戊酸钠治疗脑外伤所致精神障碍攻击行为的临床有效性和安全性较帕利哌酮单独治疗高。
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| Abstract |
Objective: To investigate the clinical efficacy and safety of paliperidone combined with valproate in the treatment of mental disorder aggression caused by brain trauma. Methods: 60 cases of patients with mental disorder attacking behavior caused by brain trauma in our hospital from August 2016 to August 2018 were randomly selected and randomly divided into two groups: one group were treated with paliperidone combined with sodium valproate (combined treatment group, 30 cases) and the other group were treated with paliperidone alone (separate treatment group, 30 cases). The MOAS scores, clinical efficacy and adverse reactions of the two groups were statistically analyzed. Results: The MOAS scores of the two groups after treatment were significantly lower than before treatment (P < 0.05); The difference of MOAS scores between the two groups before treatment was not significant (P > 0.05), the MOAS scores of the combined treatment group were significantly lower than the single treatment group after treatment (P < 0.05). The total effective rate of the combined treatment group 90.0% (27/30) was significantly higher than the single treatment group 73.3% (22/30) (P < 0.05). The difference of incidences of adverse reactions between the two groups 20.0% (6/30), 23.3% (7/30) was not significant (P > 0.05). Conclusion: The clinical efficacy and safety of paliperidone combined with sodium valproate in the treatment of mental disorder aggression caused by brain trauma are higher than paliperidone alone.
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| 关键词 |
帕利哌酮；丙戊酸钠；脑外伤所致精神障碍攻击行为
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| KeyWord |
Paliperidone; Sodium valproate; Aggressive behavior of mental disorders caused by brain trauma
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| 基金项目 |
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| 页码 |
481-482 |
杜建艳*.
帕利哌酮联合丙戊酸钠治疗脑外伤所致精神障碍攻击行为的临床有效性和安全性 [J].
国际精神病学杂志.
2019; 46; (3).
481 - 482.