认知功能检查对精神分裂症高危人群转归预测价值的研究
Predictive Value of Cognitive Function Examination in individuals at ultra high-risk for developing schizophrenia
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(5) |
| 作者 |
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| 作者单位 |
安徽医科大学附属巢湖医院 ;
合肥市第四人民医院 ;
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| 摘要 |
探讨早期认知功能检查对于精神分裂症高危人群(ultra high risk of schizophrenia,URS)转归预测的价值。 方法 本研究采用前瞻性随访研究，选择精神分裂症高危人群143例在首次就诊及三个月后采用数字广度(Digit Span，DS)、数字符号测试(Digital Symbol Test，DST)、连线测验(Trall Making Test，TMT)、词汇流畅性测验(Verbal Fluency，VF)、2-back测验、Go-Nogo测验等评估认知功能；随访20个月，将121例URS采用DSM-IV中精神分裂症诊断标准，根据转归分为健康对照组(healthy controls,HC)87例和精神分裂症(schizophrenia disease，SD)组34例，其中13例最终转归其他精神疾病患者，9例脱失患者； 结果 ①两组间在性别、年龄、受教育年限、婚姻等一般资料方面差异无统计学意义。②首次测量认知各方面差异均无统计学意义。③第二次试验时SD组在2-back测验和Go/ Nogo测验的反应时长于HC组，差异有统计学意义(P＜0.05)，说明认知损伤持续存在可能是URS最终转归成SD人群特征性标记。④SD组两次认知测量差异均无统计学意义，⑤ HC组在首次2-back测验和Go/ Nogo测验的反应时长于第二次，差异有统计学意义。 结论 早期认知功能测查（尤其是2-back测验和Go/ Nogo测验）可以预测精神分裂症高危人群的转归。
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| Abstract |
To explore the value of early cognitive function test in predicting the outcome of high risk of schizophrenia (URS) Methods A prospective follow-up study was conducted in this study. Cognitive function of individuals were assessed by Digit Span(DS)、Digital Symbol Test(DST)、Trall Making Test(TMT)、Verbal Fluency(VF)、2-back Test and Go-Nogo Test at first visit to a doctor and three months later. Following up for 20 months, 121 URS cases were divided into 87 healthy controls (HC) and 34 schizophrenia (SD) groups according to the outcome of diagnosis criteria of schizophrenia in DSM-IV. Among them, 13 cases eventually turned to other psychiatric diseases and 9 lost patients.. Results (1) There was no significant difference between the two groups in gender, age, education, marriage and other general data. (2)The different of cognitive function between two groups at the first time had no statistical significance,(3)Reaction time of 2-back test and the Go/Nogo test in SD group were longer than HC group at the second time in SD group , the difference was statistically significant(all P < 0.05), Patients at ultra high risk of schizophrenia exhibited cognitive impairment;Sustained cognitive impairment may be viewed as a marker for URS eventually outcomes of schizophrenia.(4) The different of cognitive function between the two time in SD group were not statistically significant,(5)Reaction time of 2-back test and Go/Nogo test for the first time in HC group were longer than that of the second time, the difference was statistically significant. Conclusion Early cognitive function tests (especially 2-back test and Go/Nogo test) can predict the outcome of high-risk people with schizophrenia.
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| 关键词 |
关键词 精神分裂症；超高危；认知功能
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| KeyWord |
Key words Schizophrenia；Ultra high risk；Cognitive function
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| 基金项目 |
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| 页码 |
799-802 |
刘寰忠*,潘多.
认知功能检查对精神分裂症高危人群转归预测价值的研究 [J].
国际精神病学杂志.
2019; 46; (5).
799 - 802.