| Abstract |
Objective: To investigate the changes of microbial population distribution in fecal specimens of patients with post-stroke depression. Methods: 64 patients with post-stroke depression in our hospital from August 2016 to August 2018 were randomly selected, and 60 health examinees in our hospital during the same period were randomly selected as control group. The Goods Coverage index, OTU types, Chao I index, ACE index, Simpion index, Shannon index, Evenness index, microbial community structure and relative abundance of the two groups were analyzed. Results: The OTU species in the study group were significantly more than those in the control group (P < 0.05). The Chao I index and ACE index were significantly higher than those in the control group (P < 0.05). The microbial community structure and relative abundance in Bacteroides, Proteus and Clostridium were significantly higher than those in the control group (P < 0.05), in Phytoplasma sclerenchyma was significantly lower than those in the control group (P < 0.05), and in Aminococcidae. The levels of Sciences and Research Bacteriaceae, Breviscaceae, Clostridium, Purple Fungi and Enterobacteriaceae were significantly higher than those of control group (P<0.05). The levels of Rumen Bacteriaceae, Prevotellaceae, Trichomonas and Monotoxicaceae were significantly lower than those of control group (P<0.05). The levels of Anthraceae, Clostridium, Escherichia coli/Shigella, Rosella, Lacunaria and Bromopsis were significantly lower than those of control group (P<0 The levels of Tia, Paraflagellates, Alisma, Paraptera and Giant Aeromonas were significantly higher than those of the control group (P < 0.05), while the levels of Prunella, Clostridium, Rumen Coccus and Microbacterium were significantly lower than those of the control group (P < 0.05). Conclusion: The distribution of microbial population in fecal specimens of patients with post-stroke depression varies greatly.
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