Journal of International Psychiatry

Objective To compare the efficacy and safety of risperidone and haloperidol in children with tic disorder. Methods Eighty-five children with tic disorder in our hospital were randomly assigned to a randomized digital table. 42 patients in the control group were treated with haloperidol orally, and 43 patients in the observation group were treated with risperidone. The monoamines in the two groups were compared. Changes in transmitter levels, changes in symptoms and signs, clinical outcomes, and adverse effects. Results The levels of NE and DA were significantly increased in the two groups after treatment. The 5-HT level and YGTSS score were significantly lower. The TESS scores of the observation group were lower than those of the control group at 2, 4, and 8 weeks. The YGTSS score was higher than the control at the 2nd week of treatment. The group (P<0.05); the levels of NE, DA, 5-HT in the observation group, the total effective rate and the YGTSS scores at the 4th and 8th week of treatment were not statistically significant (P>0.05). Conclusion Both risperidone and haloperidol can effectively regulate the levels of monoamine neurotransmitters in children with tic disorder, improve symptoms and signs, risperidone has slow onset and less adverse reactions, and is more suitable for childrens drug treatment.

risperidone; haloperidol; children; tic disorder; safety