| Abstract |
Objective: To explore the characteristics and manifestations of neurocognitive impairment in patients with moderate to severe late-onset depression. Methods: 50 patients with moderate to severe late-onset depression complicated with cognitive impairment were selected as observation group from February 2017 to February 2019. The neurocognitive impairment was assessed by repetitive neuropsychological state test (RBANS), verbal fluency test (VFT) and Wisconsin Card Sorting Test (WCST). The results were compared with those of the same period. The control group consisted of 50 health examinees. Hamilton Depression Scale (HAMD-17) was used to assess the severity of advanced depression in the observation group. Spearman correlation analysis was used to analyze the correlation between the severity of the disease and the above scores. Results: In the RBANS test, the scores of immediate memory, delayed memory, visual span, attention and speech ability in the observation group were lower than those in the control group (P < 0.05); the scores of VFT test in the observation group were lower than those in the control group (P < 0.05); in the WCST test, the classification number and completion of the two groups were statistically significant (P < 0.05). There was no difference in response scores required for the first classification (P > 0.05). The scores of error response, persistent error percentages, persistent error percentages and persistent response percentages in the observation group were higher than those in the control group, and the scores of conceptual level response percentages were higher than those in the control group (P < 0.05). In the observation group, HAMD-17 in the patients with late-onset depression was significantly higher than that in the control group (P < 0.05). The difference was statistically significant in moderate patients (P < 0.05). Spearman correlation analysis was used to analyze the correlation between the scores and the severity of illness. It was found that the dimensions of immediate memory, delayed memory, visual span, attention and speech ability in RBANS test were positively correlated with HAMD-17 score (r = 0.39, 0.42, 0.45, 0.38, 0.40, P < 0.05); the persistent response factors in VFT and WCST test were negatively correlated with HAMD-17 score (r=-0.40, P < 0.05). 43, -0.51, P < 0.05). CONCLUSION: For patients with moderate to severe late-onset depression, neurocognitive impairment is easy to occur. Cognitive impairment is closely related to the degree of depression, and has the most obvious impact on body composition.
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