双相情感障碍患者下丘脑-垂体-肾上腺轴功能的动态临床研究
Dynastic clinical study of Hypothalamic-pitutiary-adrenocortical function in patients with bipolar disorder
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(5) |
| 作者 |
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| 作者单位 |
厦门市仙岳医院 ;
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| 摘要 |
探讨双相情感障碍与下丘脑-垂体-肾上腺功能之间的关系。方法 选取双相情感障碍躁狂相及抑郁相急性发作期住院患者各68例，124健康成人为对照组；对躁狂组、抑郁组在治疗前和治疗后1到6周末分别用Young躁狂量表和Hamilton抑郁量表进行评，同时测定血清皮质醇水平；对照组测定1次血清皮质醇水平。 结果 双相情感障碍急性发作期患者，在治疗前和治疗后4周内，不管躁狂组还是抑郁组血清皮质醇水平均高于正常对照组（P<0.05），4周后三组无明显差异；治疗后组内比较，躁狂组在2周后出现有统计学意义的下降（P<0.05）,而抑郁组在第1周后就出现具有统计学意义的下降；且躁狂组在治疗前及治疗后4周内均高于抑郁组；躁狂组的躁狂量表评分与血清皮质醇水平具有正相关（r=0.644,p<0.01），抑郁组无类似变化；结论 双相情感障碍与下丘脑-垂体-肾上腺有密切关系，其对躁狂相的影响较大。
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| Abstract |
Objective To investigate the relationship between Bipolar disorder and Hypothalamic-pitutiary-adrenocortical function. Methods 68 inpatients with manic episode of bipolar effective disorder（mania group） and the same number of inpatients with major depressive episode（depression group） were enrolled in this study. 124 healthy controls subjects matching for gender and age were recruited. The serum cortisol level was measured before treatment and at the end of each week through 6 weeks in the mania group and the depression group.Using Yong Mania Rating Scale(YMRS) to assess the manic symptoms,the Hamilton Depression Rating Scale （HAMD）to assess the depressive symptoms. The serum cortisol level was measured only once in the control group.Results Before treatment and within 4 weeks after treatment,the serum cortisol level in the bipolar disorder was significantly higher than in the control group, and the mania group was significantly higher than the depression group,but the was not significantly difference after that time between three groups.The was statistical decrease 2 weeks after therapy in the mania group within group comparation (P<0.05), 1 week in the depression group(p<0.05). A positive correlation was found between cortisol levels and mania symptoms（r=0.644,p<0.01）,but depressive symptoms in bipolar disorder.Conclusion Bipolar disorder was closely related to the serum cortsol level,which played a more important role in manic episode.
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| 关键词 |
双相情感障碍；下丘脑-垂体-肾上腺功能；皮质醇
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| KeyWord |
Bipolar disorder ;Hypothalamic-pitutiary-adrenocortical function ;Cortisol
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| 基金项目 |
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| 页码 |
793-795 |
刘亮生*.
双相情感障碍患者下丘脑-垂体-肾上腺轴功能的动态临床研究 [J].
国际精神病学杂志.
2019; 46; (5).
793 - 795.