Journal of International Psychiatry

Objective: To investigate the changes of serum C-reactive protein and fibrinogen levels in patients with depression and their research value. Methods: Fifty-five patients with depression admitted to our hospital from July 2016 to July 2018 were selected as the observation group. Blood C-reactive protein, fibrinogen and other hemorheological indexes were tested, blood lipid and cortisol were tested, and 55 healthy people were selected as the control group during the same period. The same indexes were tested and compared between the two groups. Results: The levels of C-reactive protein and fibrinogen in the observation group were significantly higher than those in the control group (P < 0.05). The hemorheological indexes in the observation group and the control group were significantly different, including 10.1/s shear rate, high apparent blood viscosity, 307.2/s shear rate, plasma viscosity, erythrocyte sedimentation rate, hematocrit, Tk value of erythrocyte degeneration index and K value of erythrocyte sedimentation equation. The total cholesterol in the observation group was significantly lower than that in the control group, while cortisol was significantly higher than that in the control group (P < 0.05). CONCLUSION: Blood C-reactive protein, fibrinogen, blood apparent viscosity and hematocrit in patients with depression are higher than those in normal people, and blood lipid and cortisol are abnormal, suggesting that this group is susceptible to cardiovascular diseases. It is of great value to strengthen the detection of blood indicators.

depression; blood C-reactive protein; fibrinogen; lipid; cortisol