| Abstract |
To investigate the clinical value of the combination of agomelatine and cognitive behavioral intervention in patients with post-ischemic stroke and its impact on the condition. METHODS: The case selection time was from October 2018 to April 2019. The project was studied in 60 patients with post-ischemic post-stroke depression admitted to the hospital. They were divided into two groups by means of lottery (test group and reference group). The reference group used escitalopram combined with cognitive behavioral intervention, and the experimental group used agomelatine in combination with cognitive behavioral intervention. The improvement of negative emotions before and after treatment, the rate of recurrent stroke, the incidence of neurotoxicity, and the incidence of gastrointestinal reactions. RESULTS: One patient in the trial group was discharged in 3 months, and 4 patients in the reference group. The data were compared with 2 values = 1.9636, p = 0.1611. The experimental group was discharged from the hospital for 6 months and 2 patients. The reference group occurred in 8 cases. 4.3200, p value = 0.0376, the test group discharged 3 months 1 (3.33%) was lower than the reference group 4 (13.33%), but there was no significant difference between the groups P> 0.05, the test group was discharged for 6 months 2 (6.67) %) was lower than the reference group 8 (26.67%), and there was a significant difference in data comparison P<0.05; the total incidence of neurotoxicity in the test group was 1 (3.33%), which was lower than that in the reference group 7 (23.33%). Data comparison 2 = 5.1923, p = 0.0126, there was statistical significance of P < 0.05 between the groups; there was no significant difference between the experimental group and the reference group before the negative emotional treatment P> 0.05, the SDS and SAS scores of the experimental group were low after treatment In the reference group, the data were statistically significant (P<0.05); the incidence of gastrointestinal reactions in the experimental group was 1 (3.33%), which was lower than that in the reference group (20.00%). The data was compared with 2 = 4.0431, p = 0.0443. There was a significant difference between the groups (P<0.05). Conclusion: For patients with post-ischemic stroke, the combination of agomelatine and cognitive behavioral intervention can effectively reduce the rate of recurrent stroke and is also important for its neurotoxicity and gastrointestinal reactions. The effect can effectively alleviate the patients clinical negative emotions. This kind of treatment can be widely promoted and applied, so as to comprehensively promote the prognosis and rehabilitation. The combined treatment plan can be widely applied and applied.
|