| Abstract |
Objective To investigate the efficacy and safety of etomidate combined with propofol in the treatment of schizophrenia (SP) patients without convulsion electroconvulsive (MECT). Methods Ninety-six patients with SP were enrolled in our hospital. They were randomly divided into 3 groups, 32 cases each. Group A received intravenous anesthesia with propofol 2 mg/kg anesthesia, group B received anesthesia with general anesthesia with etomidate 0.3 mg/kg, and group C received anesthesia with propofol 1 mg/kg and etomidate 0.15 mg/kg. After general anesthesia and the patients eyelash reflex disappeared, succinylcholine 1 mg/kg was intravenously administered, and MECT was treated with muscle relaxation. Compare the three groups of exercise time, convulsion energy index, inhibition index, convulsion consistency index, incidence of adverse reactions, systolic blood pressure (SBP) at different time points, heart rate (HR), positive and negative symptom scale (PANSS) before and after treatment, Wechsler Memory Scale (WMS-MQ) score. Results The seizure time, convulsion energy index, inhibition index and convulsion consistency index of group C were higher than those of group B. Group B was higher than group A (P<0.05). At T1, the three groups of SBP and HR were decreased, and T2 was three groups of SBP. The HR and HR were increased. The TBP and HR of the three groups were decreased at T3 and T4. The SBP and HR of group C were higher than that of group A at T1, the SBP and HR of group B were higher than that of group A, and the group B group of group B was higher than group B with T3. The group was low (P<0.05). The hemodynamic fluctuation of group C was lower than that of group B and group A. The PANSS score of group C was lower than that of group B and group A after treatment. The PANSS score of group B was lower than that of group A, and group C was WMS-MQ. The scores were higher than those of group B and group A. The WMS-MQ score of group B was higher than that of group A (P<0.05). The incidence of agitation and muscle tremor in group B (31.25%, 34.38%) was higher than that of group A (6.25%, 6.25%). In group C (6.25%, 9.38%), the incidence of injection pain in group A (37.50%) was higher than that in group B (12.50%) and group C (12.50%) (P<0.05). Conclusion Etomidate combined with propofol induces general anesthesia in the treatment of MECT in patients with SP, which can ensure the therapeutic effect while maintaining small hemodynamic fluctuations, and has less influence on patients cognitive and memory functions. Higher security.
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