| Abstract |
Objective: To investigate the effect and prognosis of psychotherapy regimens based on the administration of aripiprazole in patients with negative symptoms of schizophrenia. METHODS: Eighty patients with negative symptoms of schizophrenia admitted to our department from September 2017 to September 2018 were enrolled in the study. They were randomized by digital table extraction and treated with aripiprazole alone (control group, n=40)Compared with combined psychotherapy (observation group, n=40) positive and negative syndrome scale total score and negative symptom score, disease severity score, depressive symptom score, quality of life score and cognitive function score . RESULTS: There was no difference in PANSS total scores and negative symptom scores between the two groups before treatment (P>0.05). At 12 weeks after treatment, the scores were lower than before treatment, and the observation group was evaluated to a lower degree than the control group. Significantly, the difference was statistically significant (P < 0.05). Disease severity score, depressive symptom score, and quality of life score showed no difference before treatment (P>0.05). After treatment, the scores of the scores were improved compared with before treatment, and the improvement of the observation group was better than that of the control group. Significantly, the difference was statistically significant (P < 0.05). Before treatment, there were no differences in the number of continuous errors, random errors, number of completed classifications, and total correct scores in the cognitive function scales (P>0.05). After treatment, the number of persistent errors and random errors were scored. The scores of the total number of correct and the number of completed classifications were increased, but the reduction and elevation of the observation group were more significant than the control group, and the difference was statistically significant (P<0.05). Conclusion: For patients with negative symptoms of schizophrenia in clinical practice, the addition of psychotherapy to aripiprazole can significantly eliminate negative symptoms, reduce the degree of depression, improve the severity of the disease, improve the quality of life, and enhance recognition. Knowledge function has very important development value.
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