艾斯西酞普兰联合计算机化认知行为治疗对老年抑郁症患者神经功能与抑郁焦虑影响
Effect of Aspirin and Computerized Cognitive Behavioral Therapy on Neurological Function and Depression and Anxiety in Elderly Patients with Depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(4) |
| 作者 |
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| 作者单位 |
江苏省镇江市精神卫生中心 ;
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| 摘要 |
目的：分析计算化的认知行为治疗（CCBT）结合艾斯西酞普兰对老年抑郁症（LLD）患者神经功能、抑郁焦虑等影响。方法：选取2016年9月至2018年9月间在本院接受治疗的LLD患者116例，随机数字表法分成2组，对照组（58例）服用艾斯西酞普兰，观察组（58例）在对照组基础上采用CCBT治疗；观察患者临床疗效，治疗前后汉密尔顿抑郁量表（HAMD）、老年抑郁量表（GDS）、NIHSS量表改善情况；ELISA法检测血清5羟色胺（5-HT）、去甲肾上腺素（NE）及C反应蛋白（CRP）含量变化。结果：观察组、对照组患者总的有效率分别为89.66%、70.69%，差异有统计学意义（P＜0.05）；治疗后观察组患者GDS、HAMD、NIHSS评分较治疗前、对照组降低，差异有统计学意义（P＜0.05）；治疗后观察组患者血清5-HT、NE含量较治疗前、对照组升高，CRP含量较治疗前、对照组降低，差异有统计学意义（P＜0.05）。结论：艾斯西酞普兰联合CCBT对LLD患者疗效显著，可改善患者抑郁症状和神经功能。
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| Abstract |
Objective:To analyze the effects of computational cognitive behavioral therapy (CCBT) combined with escitalopram on neurological function, depression and anxiety in elderly patients with depression (LLD).Methods:A total of 116 patients with LLD who were treated in our hospital from September 2016 to September 2018 were enrolled. The patients were randomly divided into two groups. The control group (58 patients) received escitalopram and the observation group (58 patients). CCBT treatment was used on the basis of the control group; the clinical efficacy of the patients was observed. Before and after treatment, the Hamilton Depression Scale (HAMD), the Geriatric Depression Scale (GDS), and the NIHSS scale were improved. The serum serotonin (5-HT) was detected by ELISA. Changes in norepinephrine (NE) and C-reactive protein (CRP) levels.Results:The total effective rate of the observation group and the control group were 89.66% and 70.69%, respectively (P<0.05). The GDS, HAMD and NIHSS scores of the observation group were lower than those before and after the treatment (P<0.05). The serum levels of 5-HT and NE in the observation group were higher than those before treatment and control group. The CRP content was lower than that before treatment and control group (P<0.05).Conclusion:Aspirin and CCBT have significant effects on patients with LLD, which can improve depressive symptoms and neurological function.
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| 关键词 |
老年抑郁症；艾斯西酞普兰；计算机化认知行为；抑郁症状；神经功能
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| KeyWord |
senile depression; escitalopram; computerized cognitive behavior; depressive symptoms; neurological function
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| 基金项目 |
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| 页码 |
659-662 |
张广华*.
艾斯西酞普兰联合计算机化认知行为治疗对老年抑郁症患者神经功能与抑郁焦虑影响 [J].
国际精神病学杂志.
2019; 46; (4).
659 - 662.