| Abstract |
Objective: To study the clinical efficacy and cognitive improvement of escitalopram and fluoxetine in the treatment of depression. Methods: From January 2017 to January 2019, 60 patients with depression were enrolled in our hospital. They were randomly divided into 2 groups, 30 patients in each group. The control group was treated with fluoxetine, and the observation group was treated with escitalopram. The HAMD and MoCA scores, clinical efficacy, quality of life, and adverse reactions were compared before and after treatment. RESULTS: In the HAMD and MoCA scores, the observation group was (24.3±1.7) points and (14.3±2.5) points, and the control group was (24.2±1.6) points and (14.3±2.6) points. The difference was (T=0.0287/0.0369, P=0.457/0.624); after treatment, the observation group was (7.1±0.3) points, (20.3±1.5) points, and the control group was (10.5±0.8) points, (17.4±1.5) points. There was a statistical difference between the two (T=3.0144/4.0268, P=0.000). In terms of treatment efficiency, the control group was 86.67% overall, and the observation group was 63.33% overall. There was a statistical difference between the two (X2=6.2174, P=0.000). In the emotional function, physiology, physical, social and other functional scores, the observation group was (76.3±2.5) points, (77.8±2.4) points, (78.9±3.2) points, (76.4±2.8) points, and the control group was (61.2±2.5) points, (60.4±2.3) points, (62.5±2.7) points, (64.5±2.9) points, there was statistical difference between them (T=3.2541/3.1574/3.5124/3.0029, P=0.000). In terms of adverse reactions, the incidence of the control group was 23.33%, and the incidence of the observation group was 6.67%. There was a statistical difference between the two (X2=7.0354, P=0.000). Conclusion: The efficacy of escitalopram in patients with depression is more significant than that of fluoxetine. The former can rapidly improve depressive symptoms and cognitive function, with fewer adverse reactions, higher safety, and improve the quality of life of patients. Therefore, it is worth applying for promotion.
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