| Abstract |
Objective To investigate the correlation between long-term dialysis hypoxia (PIH) and maintenance hemodialysis (MHD) patients with clinical prognosis and negative emotions. METHODS: We prospectively included 212 ESRD patients who had regular hemodialysis between October 2016 and December 2016. SaO2 ≤ 90% of the time is greater than 1/3 of the total treatment time as the diagnostic criteria of PIH, divided into PIH group (n = 144) and non-PIH group (n = 68). Then according to whether or not to intermittently give patients 2L/min oxygen, the patients were divided into PIH oxygen therapy group (n=80) and PIH non-oxygen therapy group (n=64). Clinical data were collected and followed up for 2 years to analyze the relationship between PIH and clinical prognosis of MHD patients, and analyze the relationship between PIH and negative emotions in patients with MHD. Results There were significant differences in smoking, cardiovascular and cerebrovascular diseases and NT-proBNP between PIH and non-PIH groups (P<0.05). There was no significant difference in other indicators (P>0.05). Logistic regression analysis showed that smoking, cardiovascular and cerebrovascular diseases and NT-proBNP were independent factors in the occurrence of PIH in MDH patients (P<0.05). During the follow-up period, cardiovascular events occurred in 48 of 212 patients, and 56 patients were hospitalized and died in 56 cases (death due to cardiovascular disease, cerebrovascular accident, infection, and multiple organ failure). The incidence of cardiovascular events, hospitalization, and mortality were significantly higher in the PIH group than in the non-PIH group (P<0.05). The incidence of cardiovascular events, hospitalization, and mortality were significantly higher in the PIH non-oxygen therapy group than in the PIH oxygen therapy group. (P<0.05). The survival analysis of PIH group and non-PIH group, PIH non-oxygen therapy group and PIH oxygen therapy group are shown in Figure 1 and Figure 2, respectively, there are significant differences (P <0.05). The SAS score and SDS score of PIH group were higher than those of non-PIH group (P<0.05). The SAS score and SDS score of PIH oxygen therapy group were higher than those of non-PIH oxygen therapy group (P<0.05).Conclusion The incidence of PIH in patients with MHD is high, which can significantly increase the incidence of cardiovascular events, hospitalization and mortality. Moderate oxygen therapy can help reduce the adverse effects of PIH, but it may aggravate negative emotions such as anxiety and depression.
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