| Abstract |
Objective To investigate the effect of serum homocysteine (Hcy) and insulin resistance on cognitive status in patients with depression. Methods A total of 128 patients with depression who were admitted to our hospital between January 2015 and January 2018 were selected as the observation group. 128 healthy volunteers who had come to our hospital for health examination during the same period were selected as the control group. The serum markers and cognitive function of the two groups were compared. Among the 128 patients in the observation group, 42 patients had cognitive impairment associated with cognitive impairment and the remaining 86 patients without cognitive impairment were normal. The common serum markers in the two groups were compared to analyze the correlation between serum Hcy and insulin resistance and cognitive status of patients with depression. Results There was no significant difference in serum fasting blood glucose (FBG) between the observation group and the control group (p>0.05). Serum Hcy, fasting insulin (FINS) and insulin resistance index (HOMA-IR) were higher in the observation group than in the control group. In the control group, the scores of the cognitive function of the MOCA in the observation group were lower than those in the control group, and the difference was statistically significant (p<0.05). Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP), Hcy, HOMA-IR, glycated hemoglobin in patients with cognitive impairment (HbAlc), fasting insulin (FBI), FINS, and FBG levels were higher than those in the normal group. HGB levels were lower than those in the normal group. The difference was statistically significant (p<0.05). Logistic multivariate analysis showed that high TC, high TG, high LDL-C, high hs-CRP, high Hcy, high HOMA-IR, high HbAlc, high FBI, and high FINS risk depression in patients with cognitive impairment Factors (p<0.05). Conclusions There is a correlation between serum Hcy level, insulin resistance and cognitive impairment in patients with depression. The response to high TC, high TG, high LDL-C, high hs-CRP, high Hcy, high HOMA-IR, high HbAlc, high FBI, Depression patients with high FINS levels are monitored to prevent cognitive impairment.
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