Journal of International Psychiatry

Objective To investigate the effect of serum thyroxine on depression in patients with primary insomnia. Method A total of 138 patients with primary insomnia admitted to our hospital from June 2015 to June 2017 were enrolled. The patients were divided into depression group (n=35) and non-depression group according to the Hamilton Depression Scale (HAMD) score. (n=103). Serum thyroxine levels were compared between depressed and non-depressed patients. The correlation between HAMD scores and serum thyroxine levels in patients with primary insomnia was analyzed. Serum thyroxine levels in the depression group before and after treatment were compared. Results There were no significant differences in serum levels of triiodothyronine (T3), tetraiodothyronine (T4) and free tetraiodothyronine (FT4) between the two groups (p>0.05); depression The serum free triiodothyronine (FT3) level was lower in the group than in the non-depressed group, and the serum thyroid stimulating hormone (TSH) level was higher than that in the non-depressed group, the difference was statistically significant (p<0.05). The HAMD score was (15.28±2.77) in the depression group and (4.92±1.22) in the non-depressed group. The HAMD scores of patients in the depression group were negatively correlated with serum TSH and T3 levels (p<0.05). There was no significant difference in serum T3, T4 and FT4 levels between the patients before and after treatment (p>0.05). After treatment, the serum FT3 level and TSH level were lower than those in the pre-treatment depression group, and the difference was statistically significant (p<0.05). Conclusion Depressive mood in patients with primary insomnia can lead to disorder of serum thyroxine levels, and improving symptoms of primary insomnia can improve thyroxine levels.

Primary insomnia; Thyroxine; Depression