| 摘要 |
目的探究血清血管紧张素Ⅱ水平和妊娠高血压妇女焦虑抑郁的关系分析，旨在为临床治疗妊娠高血压患者的提供科学依据。方法选取2017年1月至2019年2月于我院接受治疗的60例妊娠高血压妇女为研究对象，统计所有患者焦虑水平（汉密尔顿焦虑量表,HAMA）和抑郁水平（汉密尔顿抑郁量表,HAMD），并比较不同焦虑、抑郁水平患者的血管紧张素Ⅱ水平，使用Pearson法分析焦虑、抑郁与血管紧张素Ⅱ的相关性。结果HAMA评分＜7分患者血管紧张素Ⅱ水平为125.83±20.05pg/ml，HAMA评分为7～14分患者血管紧张素Ⅱ水平为242.44±53.78 pg/ml，HAMA评分为15～21分患者血管紧张素Ⅱ水平为357.66±103.74 pg/ml，HAMA评分＞21分患者血管紧张素Ⅱ水平为443.61±132.19pg/ml，差异具有统计学意义（P＜0.05）；HAMD评分＜7分患者血管紧张素Ⅱ水平为131.50±27.62pg/ml，HAMD评分为7～16分患者血管紧张素Ⅱ水平为239.74±61.22 pg/ml，HAMD评分为17～24分患者血管紧张素Ⅱ水平为344.82±102.52 pg/ml，HAMD评分＞24分患者血管紧张素Ⅱ水平为432.48±121.06 pg/ml，差异具有统计学意义（P＜0.05）；Pearson法分析结果显示，HAMA评分、HAMD评分与血管紧张素Ⅱ水平的相关系数r分别为0.403、0.517。结论血清血管紧张素Ⅱ水平和妊娠高血压妇女焦虑抑郁程度呈正相关关系，血清血管紧张素Ⅱ水平越高，提示患者心理健康水平越差，临床上应该加以重视。
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| Abstract |
objective To explore the relationship between serum angiotensin II level and anxiety and depression in pregnant women with hypertension, aiming to provide scientific basis for clinical treatment of patients with pregnancy-induced hypertension. Method Sixty pregnant women with pregnancy-induced hypertension who were treated in our hospital from January 2017 to February 2019 were selected as subjects. All patients anxiety levels (Hamilton Anxiety Scale, HAMA) and depression levels (Hamilton Depression Scale, HAMD) were counted. Angiotensin II levels were compared in patients with different levels of anxiety and depression. Correlation between anxiety and depression and angiotensin II was analyzed using the Pearson method. Result HAMA score <7 points, angiotensin II level was 125.83±20.05pg/ml, HAMA score was 7-14 points, angiotensin II level was 242.44±53.78 pg/ml, and HAMA score was 15-21 points. The level of hormone II was 357.66±103.74 pg/ml, and the level of angiotensin II was 443.61±132.19pg/ml in patients with HAMA score>21 points (P<0.05). HAMD score <7 points, angiotensin II level was 131.50±27.62pg/ml, HAMD score was 7-17 points, angiotensin II level was 239.74±61.22 pg/ml, and HAMD score was 17-24 points. The level of hormone II was 344.82±102.52 pg/ml, and the level of angiotensin II was 432.48±121.06 pg/ml with HAMD score>24 points(P<0.05). Pearson analysis showed that the correlation coefficients r of HAMA score, HAMD score and angiotensin II level were 0.403 and 0.517, respectively. Conclusion There was a positive correlation between serum angiotensin II level and anxiety and depression in pregnant women with hypertension. The higher the serum angiotensin II level, the worse the mental health level of patients, and should be paid attention to in clinical practice.
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