血浆置换在神经内科自身免疫性疾病临床安全性及精神抑郁指标影响
Effect of plasma exchange on clinical safety and depression index of neurological autoimmune diseases
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(3) |
| 作者 |
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| 作者单位 |
南阳市中心医院 ;
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| 摘要 |
目的：研究分析血浆置换在神经内科自身免疫性疾病中的临床安全性及精神抑郁指标影响。方法：选取2014年1月至2017年1月在本院治疗的自身免疫性疾病患者80例，根据患者的治疗方式分为采取血浆置换患者为研究组（n=40）及采取注射免疫球蛋白治疗的患者为对照组（n=40），观察两组患者治疗前后的神经功能及焦虑、抑郁症状的改善状况，并对治疗疗效进行分析。结果：对比两组患者神经功能缺损评分可知，治疗完成后1w时，研究组与对照组神经功能缺陷评分对比差异无统计学差异( P>0.05) ，治疗完成后2w时，研究组神经功能缺陷评分优于对照组患者，差异有统计学意义（P<0.05）；对比两组患者治疗完成1w、2w后的各项指标评分可知，治疗后1w时研究组与对照组各项指标对比差异无统计学意义（P>0.05），治疗后2w时研究组各项指标显著低于对照组，差异有统计学意义（P<0.05）；对比两组患者焦虑自评量表（SAS）评分、抑郁自评量表（SDS）评分可知，治疗完成后1w时，研究组与对照组SAS、SDS评分对比无统计学差异（P>0.05），治疗完成后2w时，研究组SAS、SDS评分由于对照组，差异有统计学意义（P<0.05）；对两组患者治疗1w及2w的疗效进行比较可知，治疗完成后1w，研究组与对照组患者的疗效差异无统计学意义（P>0.05）。而2w时，研究组效果显著优于对照组，差异有统计学意义（P<0.05）。结论：注射免疫性球蛋白疗法及血浆置换疗法均为治疗自身免疫性疾病患者的有效方法，而血浆置换疗法疗效更为显著，对患者精神抑郁状态改善更为有效。
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| Abstract |
Objective: To study the clinical safety of plasma exchange in neurological autoimmune diseases and the influence of mental depression index. Methods: Eighty patients with autoimmune diseases treated in our hospital from January 2014 to January 2017 were selected. According to the treatment of patients, patients with plasma exchange were divided into study group (n=40) and treated with injection of immunoglobulin. The patients were in the control group (n=40). The neurological function and the improvement of anxiety and depressive symptoms were observed before and after treatment, and the therapeutic effects were analyzed.Results: Comparing the scores of neurological deficits between the two groups, there was no significant difference in the scores of neurological deficits between the study group and the control group at 1w after treatment (P>0.05). At 2w after the completion of treatment, the neurological deficit scores of the study group were excellent. In the control group, the difference was statistically significant (P<0.05). Comparing the scores of the indicators after 1w and 2w of treatment in the two groups, the difference between the study group and the control group at 1w after treatment was not statistically significant. Significance (P>0.05), the indexes of the study group were significantly lower than the control group at 2w after treatment, the difference was statistically significant (P<0.05). The self-evaluation of anxiety self-rating scale (SAS) and depression were compared between the two groups. The scale of the scale (SDS) showed that there was no significant difference in the scores of SAS and SDS between the study group and the control group at 1 week after treatment (P>0.05). At 2 weeks after the completion of treatment, the SAS and SDS scores of the study group were due to the control group. The difference was statistically significant (P<0.05). Comparing the therapeutic effects of 1w and 2w in the two groups, the difference between the study group and the control group was not statistically significant (P>0.05). At 2w, the effect of the study group was significantly better than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Injecting immunoglobulin therapy and plasmapheresis are effective methods for the treatment of patients with autoimmune diseases, and plasma exchange therapy is more effective, and it is more effective to improve the symptoms of patients.
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| 关键词 |
血浆置换；注射免疫球蛋白；自身免疫性疾病；临床安全性分析；精神抑郁指标
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| KeyWord |
Plasma exchange; injection of immunoglobulin; autoimmune disease; clinical safety analysis;
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| 基金项目 |
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| 页码 |
590-592 |
秦慧兵*.
血浆置换在神经内科自身免疫性疾病临床安全性及精神抑郁指标影响 [J].
国际精神病学杂志.
2020; 47; (3).
590 - 592.