| Abstract |
Objective: To explore the effects of intravenous and inhalation general anesthesia on postoperative cognitive impairment (POCD) and quality of resuscitation in elderly patients undergoing surgery. Methods: 88 elderly patients undergoing surgery from May 2017 to May 2019 were randomly divided into control group (sevoflurane anesthesia by inhalation) and observation group (propofol anesthesia by intravenous maintenance) with 44 cases in each group. The anesthetic effect of the two groups was compared. Results: (1) The extubation time and recovery time of the observation group were shorter than those of the control group, and the incidence of restlessness was lower than that of the control group, all P < 0.05. (2) The levels of plasma interleukin-6 (IL-6) in T0, T1, T2 and T3 of the two groups were compared, P > 0.05; the levels of S100 beta at T0 and T3 of the two groups were compared, P > 0.05; the levels of 100 beta at T1 and T2 of the observation group were lower than those of the control group, P < 0.05. (3) Simple Mental State Examination Scale (MMSE) score of the two groups at the same time, P > 0.5; POCD incidence of the two groups, P > 0.05; (4) The incidence of hypotension, nausea and vomiting in the observation group was lower than that in the control group, P < 0.05; the incidence of bradycardia in the observation group was higher than that in the control group, P < 0.05; the incidence of analgesia incompleteness in the two groups was higher, P > 0.05. CONCLUSION: Intravenous anesthesia can shorten the recovery time and extubation time, reduce intraoperative hypotension and restlessness during extubation, and is conducive to postoperative recovery. It can reduce the occurrence of postoperative nausea and vomiting. It may be the first choice of maintenance anesthesia for elderly patients undergoing surgery, but intravenous anesthesia is more likely to cause bradycardia, and patients with chronic arrhythmia need to use cautiously.
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