叶酸、维生素B12联合多奈哌齐对阿尔茨海默病患者认知功能及精神行为症状的影响
Effects of folic acid, vitamin B12 and donepezil on cognitive function and mental behavior in patients with Alzheimers disease
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(1) |
| 作者 |
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| 作者单位 |
鹤壁煤业（集团)有限责任公司总医院神经内科 ;
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| 摘要 |
分析阿尔茨海默病患者应用叶酸、维生素B12、多奈哌齐联合治疗后效果。方法 采用随机数字表法将我院111例阿尔茨海默病患者分组，对照组55例给予多奈哌齐治疗，观察组56例联合叶酸、维生素B12治疗，对比两组患者治疗后血清神经递质水平、血清细胞因子水平、认知功能、精神行为症状及临床疗效。结果 观察组治疗后Glu、BDNF、GABA、VEGF、5-HT、Ach水平、MMSE评分及总有效率均高于对照组，IL-6、INF-γ水平及NPI评分低于对照组（P<0.05）。结论 叶酸、维生素B12联合多奈哌齐能够有效改善阿尔茨海默病患者精神行为症状及认知功能，其机制与调节血清神经递质及细胞因子水平有关。
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| Abstract |
Objective To analyze the effects of folic acid, vitamin B12 and donepezil in patients with Alzheimers disease. Methods A total of 111 patients with Alzheimers disease were enrolled in our hospital. The control group was treated with donepezil in 55 patients. The observation group was treated with folic acid and vitamin B12. The serum neurotransmitter levels in the two groups were compared. Serum cytokine levels, cognitive function, mental behavioral symptoms and clinical efficacy. Results The Glu, BDNF, GABA, VEGF, 5-HT, Ach levels, MMSE scores and total effective rate were higher in the observation group than in the control group. The IL-6, INF-γ levels and NPI scores were lower than the control group (P< 0.05). Conclusion Folic acid, vitamin B12 and donepezil can effectively improve mental behavior and cognitive function in patients with Alzheimers disease. The mechanism is related to the regulation of serum neurotransmitters and cytokines.
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| 关键词 |
叶酸；维生素B12；多奈哌齐；阿尔茨海默病；认知功能；精神行为症状
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| KeyWord |
folic acid; vitamin B12; donepezil; Alzheimers disease; cognitive function; mental behavior symptoms
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| 基金项目 |
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| 页码 |
101-103 |
刘得伟*.
叶酸、维生素B12联合多奈哌齐对阿尔茨海默病患者认知功能及精神行为症状的影响 [J].
国际精神病学杂志.
2020; 47; (1).
101 - 103.