帕罗西汀治疗老年骨折术后伴焦虑抑郁的效果及对心理状态与疼痛介质的影响分析
Effect of paroxetine on anxiety and depression after senile fracture and its influence on psychological state and pain media
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(6) |
| 作者 |
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| 作者单位 |
商丘市中医院骨科 ;
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| 摘要 |
分析老年骨折术后伴焦虑抑郁患者应用帕罗西汀治疗后心理状态与疼痛介质水平的变化。方法 将我院2017年3月至2018年9月期间收治的103例老年骨折术后伴焦虑抑郁患者，依据采用随机数字表法分为对照组51例及观察组52例，对照组患者给予心理、疼痛及康复指导，观察组患者增加帕罗西汀口服，对比两组患者治疗后焦虑抑郁情绪变化、疼痛介质水平变化。结果 治疗后，观察组HAMA、HAMD、VAS评分及NO、5-HT、PGE2水平均低于对照组（P<0.05）。结论 帕罗西汀能够有效调节老年骨折术后伴焦虑抑郁患者疼痛介质及神经递质水平，减轻疼痛，缓解焦虑抑郁情绪。
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| Abstract |
Objective To analyze the changes of psychological state and pain mediator level after treatment with paroxetine in elderly patients with anxiety and depression. Methods 103 elderly patients with anxiety and depression who were admitted to our hospital from March 2017 to September 2018 were divided into 51 cases in the control group and 52 cases in the observation group according to the random number table. Pain and rehabilitation guidance, patients in the observation group increased the oral administration of paroxetine, compared with changes in anxiety and depression after treatment, and changes in pain mediator levels. Results After treatment, the HAMA, HAMD, VAS scores and NO, 5-HT and PGE2 levels in the observation group were lower than those in the control group (P<0.05). Conclusion Paroxetine can effectively regulate the pain mediators and neurotransmitters in elderly patients with anxiety and depression, relieve pain and alleviate anxiety and depression.
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| 关键词 |
帕罗西汀；老年；骨折；焦虑抑郁；心理状态；疼痛介质
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| KeyWord |
paroxetine; senile; fracture; anxiety and depression; mental state; pain medium
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| 基金项目 |
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| 页码 |
1077-1079 |
赵玉鑫*.
帕罗西汀治疗老年骨折术后伴焦虑抑郁的效果及对心理状态与疼痛介质的影响分析 [J].
国际精神病学杂志.
2019; 46; (6).
1077 - 1079.