Journal of International Psychiatry

【Abstract】： Objective Our study is to explore abnormal brain activity areas in first-episode depressed patients with somatic pain by using resting-state functional magnetic resonance imaging(rs-fMRI) and the relationship between depressive symptoms and somatic pain. Methods Thirty-two depressed patients(sixteen with somatic pain and sixteen without somatic pain) diagnosed MDD by the criteria of DSM-IV were scanned by rs-fMRI. ReHo was used to analyze the difference between depressed patients with somatic pain and without somatic pain. Results (1)ReHo values in the Left postcentral gyrus and the left precentral gyrus (sensorimotor area) of depressed patients with somatic pain were significantly higher than those without somatic pain（tleft postcentral gyrus=4.93，pleft postcentral gyrus<0.001；tleft precentral gyrus=4.57，pleft precentral gyrus<0.001）; (2)The mean pain score of BPI was positively correlated with ReHo value in the left postcentral gyrus (r = 0.544, P = 0.001) and the left precentral gyrus (r = 0.550, P = 0.001). Conclusion ReHo changes in sensorimotor area play an important role in depressed patients with somatic pain.

【Key words】 Major depressive disorder; Magnetic resonance imaging; Pain; Regional homogeneity.