| Abstract |
[Abstract] Objective To investigate the detection value of serum nerve growth factor (NGF), total bilirubin (TBiL), and uric acid (UA) in bipolar disorder, schizophrenia and healthy people.Methods A total of 133 patients with bipolar disorder were enrolled in the study group. In the same period, 133 patients with schizophrenia were selected as the control group and 133 healthy subjects were selected as the healthy group. Blood samples were taken after admission and the levels of NGF, TBiL, and UA were measured. Statistical analysis of serum UA, TBiL, NGF levels, factors affecting the onset of bipolar disorder, serum index levels and [degree of depression (HAMD), mania (YMRS)] scores in patients with different levels of disease (depression and mania), Serum indicators were correlated with disease severity and analyzed for diagnostic efficacy. Results The UA of the study group was higher than that of the control group and the healthy group. The TBiL and NGF were lower than the control group and the healthy group (P<0.05). UA, TBiL and NGF were all important factors affecting the incidence of bipolar disorder (P<0.05). There were significant differences in serum index, HAMD and YMRS scores between depression and different levels of mania. With the increase of depression and mania, UA, HAMD and YMRS showed an increasing trend, and TBiL and NGF showed a decreasing trend (P<0.05). UA and There was a positive correlation between depression and mania. TBiL and NGF were negatively correlated with depression and mania (P<0.05). NGFAUC was 0.783, which was greater than UA (0.645) and TBiL (0.651). When the cutoff value was less than or equal to 43.74, the diagnostic sensitivity was It is 67.67% and the specificity is 78.95%.Conclusions The serum levels of UA, TBiL and NGF in patients with bipolar disorder are abnormally higher than those in patients with schizophrenia and healthy people. It has a significant correlation with the degree of illness, and may have certain value in the diagnosis and assessment of bipolar disorder.
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