利培酮治疗首发精神分裂症的效果及对认知功能与血脂代谢的影响分析
Effect of risperidone on first-onset schizophrenia and its effect on cognitive function and blood lipid metabolism
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(4) |
| 作者 |
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| 作者单位 |
河南省驻马店市精神病医院精神科 ;
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| 摘要 |
分析首发精神分裂症患者应用利培酮治疗后疗效及认知功能、血脂代谢水平变化。方法 将2013年3月至2018年10月期间我院收治的120例首发精神分裂症患者，依据患者入院先后顺序分为对照组及观察组两组，每组各60例，对照组患者给予奥氮平口服治疗，观察组患者应用利培酮口服治疗，对比两组患者治疗后症状评分、认知功能、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)及血清三酰甘油(TG)水平变化。结果 两组患者治疗后PANSS评分均低于治疗前，MCCB评分高于治疗（P<0.05），组间比较无统计学意义（P>0.05）；观察组治疗后HDL-C水平高于对照组，LDL-C、TC、TG水平低于对照组（P<0.05）。结论 利培酮能够有效改善首发精神分裂症患者认知功能及症状，且对血脂水平影响小。
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| Abstract |
Objective To analyze the effects of risperidone in patients with first-onset schizophrenia and the changes in cognitive function and lipid metabolism. Methods A total of 120 patients with first-onset schizophrenia who were admitted to our hospital from March 2013 to October 2018 were divided into two groups: the control group and the observation group, with 60 patients in each group. Oral treatment with tazapine. Patients in the observation group were treated with risperidone. The symptoms score, cognitive function, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and Changes in total cholesterol (TC) and serum triacylglycerol (TG) levels. Results The PANSS scores of the two groups after treatment were lower than before treatment, and the MCCB score was higher than the treatment (P <0.05). There was no significant difference between the groups (P> 0.05). The HDL-C level in the observation group was higher than that in the control group The levels of LDL-C, TC and TG were lower than those in the control group (P <0.05). Conclusion Risperidone can effectively improve cognitive function and symptoms of patients with first-onset schizophrenia, and has little effect on blood lipid levels.
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| 关键词 |
奥氮平；首发精神分裂症；认知功能；血脂代谢
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| KeyWord |
Olanzapine; First episode schizophrenia; Cognitive function; Lipid metabolism
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| 基金项目 |
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| 页码 |
715-717 |
张明松*.
利培酮治疗首发精神分裂症的效果及对认知功能与血脂代谢的影响分析 [J].
国际精神病学杂志.
2020; 47; (4).
715 - 717.