| Abstract |
Objective To explore the correlation between white matter lesions (WML) and the severity and cognitive function changes of patients with depression.Methods A total of 98 patients with depression were selected and divided into observation group (WML group) 37 and control group (NWML group) 61,according to whether they had white matter lesions.Fazekas classification, Hamilton Depression Scale (HAMD-17), and Montreal Cognitive Assessment Scale (MoCA) were performed on all patients,and blood biochemical indicators were collected.Patients were compared for general clinical data,blood biochemical indicators,severity of depression, and cognitive function,and further analyze the relationship between the burden of white matter lesions and the severity of depressive symptoms and changes in cognitive function.Results Fazekas classification was positively correlated with HAMD total scores and negatively correlated with MoCA total scores (P≤0.05).Among patients aged≥50 years, after controlling for age, hypertension, years of education, TC, LDL-C,the Fazekas classification was still positively correlated with the total HAMD score (r= 0.547, P = 0.001); after controlling for age, hypertension, years of education, TG, and ApoE,the total MoCA score was still negatively correlated with sleep disturbance factors (r= -0.399, P = 0.026). Conclusion In patients with depression, especially elderly patients, the more severe the WML, the more severe the symptoms of depression, and the more obvious the impairment of cognitive function,and cognitive impairment may be related to sleep disorder.
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