文拉法辛对产后抑郁患者负面情绪、睡眠质量及认知功能的影响
Effects of Venlafaxine on Negative Emotion, Sleep Quality and Cognitive Function in Patients with Postpartum Depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2021, 48(2) |
| 作者 |
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| 作者单位 |
郑州市中心医院产二科 ;
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| 摘要 |
分析产后抑郁患者应用文拉法辛治疗后睡眠质量、负面情绪及认知功能变化。方法 采用随机数字表法将我院91例产后抑郁患者进行分组，对照组45例给予阿米替林口服治疗，观察组46例给予文拉法辛口服治疗，对比两组患者治疗后炎性因子水平、血清指标水平、认知功能变化、负面情绪、睡眠质量及生活质量变化。结果 治疗后，观察组NE、5-HT、DA水平及SF-36、MMSE评分高于对照组，TNF-α、IL-6、IL-1β水平及PSQI、HAMD评分均低于对照组（P<0.05）。结论 文拉法辛能够有效改善产后抑郁患者负面情绪、睡眠质量及认知功能，其机制与调节细胞因子及神经递质水平有关。
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| Abstract |
Objective To analyze the changes of sleep quality, negative emotion and cognitive function in patients with postpartum depression treated with venlafaxine. Methods A random number table was used to group 91 postpartum depression patients in our hospital. The control group was treated with amitriptyline orally and the observation group was treated with venlafaxine. The inflammatory factors were compared between the two groups. Levels, serum index levels, changes in cognitive function, negative emotions, changes in sleep quality and quality of life. Results After treatment, the levels of NE, 5-HT, DA, SF-36, and MMSE in the observation group were higher than those in the control group. The levels of TNF-α, IL-6, IL-1β, and PSQI and HAMD scores were lower than those in the control group (P <0.05). Conclusion Venlafaxine can effectively improve the negative mood, sleep quality and cognitive function of postpartum depression patients, and its mechanism is related to the regulation of cytokines and neurotransmitters.
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| 关键词 |
文拉法辛；产后抑郁；负面情绪；睡眠质量；认知功能
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| KeyWord |
venlafaxine; postpartum depression; negative emotions; sleep quality; cognitive function
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| 基金项目 |
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| 页码 |
306-308 |
张静华*.
文拉法辛对产后抑郁患者负面情绪、睡眠质量及认知功能的影响 [J].
国际精神病学杂志.
2021; 48; (2).
306 - 308.