| Abstract |
Objective To study the correlation between the levels of serum orphanin (NC) and leptin (LP) and postpartum depression. Methods A total of 220 pregnant women from December 2017 to December 2019 were selected as the research object. The women with Edinburgh postpartum depression scale (EPDS) ≥ 10 were set as the depression group, and the women with EPDS <10 were set as the non-depression group. The age, parity, delivery mode, weight, gestational week, neonatal weight, neonatal gender, NC, and LP were compared between the two groups, and the correlation between NC, LP and postpartum depression was analyzed using the Pearson linear correlation method. Multivariate logistic regression was used to analyze the risk factors for postpartum depression. Results Of the 220 women, 98 had EPDS ≥ 10 points, and 122 had EPDS <10 points. There were no significant differences in parity, delivery methods, gestational weeks, neonatal body, and sex of the newborns between the two groups (P> 0.05). The age and weight of the depression group were significantly higher than those of the non-depression group. Statistical significance (P <0.05). The NC of the depression group was significantly higher than that of the non-depression group, and the LP was significantly lower than that of the non-depression group. The differences were statistically significant (P <0.05). By Pearson linear correlation analysis, NC was positively correlated with postpartum depression (P <0.05), and LP was negatively correlated with postpartum depression (P <0.05). By multivariate logistic regression analysis, age, weight, NC, and LP were independent risk factors for postpartum depression. Conclusion NC is positively correlated with postpartum depression, and LP is negatively correlated with postpartum depression, which prompts monitoring of NC and LP levels,can prevent postpartum depression.
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