Journal of International Psychiatry

Objective To analyze the effect of butylphthalide sodium chloride injection combined with memantine in patients with vascular dementia caused by hepatic encephalopathy. Methods Random number table method was used to group 85 patients with vascular dementia caused by hepatic encephalopathy in the hospital. The control group was treated with memantine and the observation group was treated with memantine combined with butylphthalide sodium chloride injection. The two groups were compared. Cognitive function, conscious behavior, dementia level, oxidative stress index level, quality of life and clinical efficacy after treatment. Results After 2 and 4 weeks of treatment, the CDR score of the observation group was lower than that of the control group, and the MoCA and MMSE scores were higher than those of the control group. After 4 weeks of treatment, the SOD level, ADL score, and total effective rate of the observation group were higher than those of the control group, and the MDA level was low. In the control group (P <0.05). Conclusion Butylphthalide sodium chloride injection combined with memantine can effectively improve the consciousness, behavior and cognitive function of patients with vascular dementia caused by hepatic encephalopathy, and improve the quality of life. The mechanism is related to antioxidant stress.

butylphthalide sodium chloride injection; memantine; hepatic encephalopathy; vascular dementia; conscious behavior; cognitive function