利培酮联合新型抗抑郁药物治疗精神分裂症阴性症状研究进展

Research progress of risperidone combined with new antidepressants in the treatment of negative symptoms of schizophrenia

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2020, 47(5)
作者
作者单位

上海市普陀区精神卫生中心 ;
南京脑科医院 ;
上海市精神卫生中心 ;

摘要
精神分裂症阴性症状临床疗效较差,且预后不良,严重影响患者的正常生活和身体健康。目前有研究证据支持第二代抗精神病药物联合新型抗抑郁药物可改善精神分裂症患者阴性症状,但由于抗抑郁药的异质性,研究结果难以做出统一的结论。非典型抗精神病药利培酮,广泛应用于精神分裂症的治疗,现综述其联合新型抗抑郁药物使用时对精神分裂症患者阴性症状以及社会功能改善情况,优化精神分裂症的临床治疗有指导意义。
Abstract
The negative symptoms of schizophrenia have poor clinical efficacy and poor prognosis, which seriously affects the normal life and health of patients. At present, there is research evidence supporting that the second generation of antipsychotics combined with new antidepressants can improve the negative symptoms of schizophrenia patients, but due to the heterogeneity of antidepressants, it is difficult to make a unified conclusion. Risperidone, an atypical antipsychotic drug, is widely used in the treatment of schizophrenia. This article reviews its combined use of new antidepressant drugs for the improvement of negative symptoms and social functions of schizophrenics, and for the optimization of clinical treatment of schizophrenia.
关键词
利培酮;抗抑郁药;精神分裂症;阴性症状;社会功能
KeyWord
Risperidone;Antidepressants;Schizophrenia;Negative symptoms;Social function
基金项目
页码 881-884
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裘建萍*,黄昱淳,李凤婷,喻东山,陆峥. 利培酮联合新型抗抑郁药物治疗精神分裂症阴性症状研究进展 [J]. 国际精神病学杂志. 2020; 47; (5). 881 - 884.

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