Journal of International Psychiatry

[Abstract] Objective To study the effect of angiotensin-converting enzyme inhibitor on cognitive dysfunction of chronic heart failure (CHF). Methods A total of 113 patients with CHF cognitive dysfunction from March 2016 to March 2019 in our hospital were selected as the research object, and were divided into 56 cases in the control group and 57 cases in the study group according to the numerical random table method. The Montreal Cognitive Function Assessment Scale (MoCA) before and after treatment were compared. Results After treatment, the visual space and executive ability, naming, attention, language, abstraction, memory, orientation score and total MoCA score of the control group were significantly lower than those of the study group, and the differences were statistically significant (P<0.05). Conclusion ACEI can significantly improve the cognitive function such as visual space, executive ability, naming, orientation, etc. in CHF patients, and its mechanism may be related to improving the cerebral perfusion of patients with CHF and promoting the release of related neurotransmitters.

Key words ACEI; Chronic Heart Failure; Ventricular Remodeling; Visual Space and Executive Ability; Memory