冠心病心绞痛合并抑郁症与低T3综合征、HCY及CRP的相关性-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

冠心病心绞痛合并抑郁症与低T3综合征、HCY及CRP的相关性

The correlation between angina pectoris of coronary heart disease with depression and Low T3 syndrome, Hcy and CRP

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DOI
刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2020, 47(6)
作者	丁怀莹*,费玉玲,邵岩,张艳,哈永琴,王保和,
作者单位	天津市滨海新区中医医院 ; 天津市滨海新区中医医院 ; 天津中医药大学第二附属医院 ;
摘要	探讨冠心病心绞痛合并抑郁症与低T3综合征、HCY及CRP的相关性。方法选取199例冠心病心绞痛患者，按照HAMD-17分为观察组（合并抑郁症）82例和对照组（未合并抑郁症）117例，比较两组FT3、FT4、T3、T4、TSH、rT3、HCY、CRP水平。结果冠心病心绞痛合并抑郁症的患病率为41.21%。观察组发生低T3综合征的患病率为29.27%，明显高于对照组(P＜0.05)，比值比(OR)为2.13。观察组rT3、HCY、CRP升高例数，以及FT3、T3降低例数，与对照组相比均达到统计学差异(P＜0.05)。观察组Pearson 相关分析显示：HAMD 评分与 TSH、HCY呈正相关 (P＜0.01) ，与FT4、T4呈负相关 (P＜0.01) ；Spearman相关分析表明： HAMD 评分与rT3、CRP呈正相关 (P＜0.01），与FT3、T3呈负相关 (P＜0.01) 。Logistic回归多因素分析显示：两组rT3和CRP升高、FT3降低均达到统计学差异(P＜0.05)。结论冠心病心绞痛合并抑郁症与低T3综合征、HCY及CRP具有相关性，rT3、FT3、CRP是冠心病心绞痛合并抑郁症的危险因素。
Abstract	Objective: To explore the correlation between Angina pectoris of Coronary heart disease with Depression and Low T3 syndrome, Hcy and CRP. Methods: According to HAMD-17, 199 patients with Angina pectoris of Coronary heart disease were divided into observation group (82 patients with depression) and control group (117 patients without depression). The levels of FT3, FT4, T3, T4, TSH, rT3, Hcy and CRP were compared between the two groups. Results: The prevalence of Angina pectoris of Coronary heart disease with Depression was 41.21%. The prevalence of Low T3 syndrome in the observation group was 29.27%, significantly higher than that in the control group (P＜0.05), and the ratio (OR) was 2.13. The increasing number of rT3, Hcy and CRP and the decreasing number of FT3 and T3 in the observation group were significantly higher than those in the control group (P＜0.05). Pearson correlation analysis showed that HAMD score was positively correlated with TSH and Hcy (P＜0.01), negatively correlated with FT4 and T4 (P＜0.01); Spearman correlation analysis showed that HAMD score was positively correlated with rT3 and CRP (P＜0.01), and negatively correlated with FT3 and T3 (P＜0.01). Logistic regression analysis showed that the differences of rT3, FT3 and CRP between the two groups were statistically significant (P＜0.05). Conclusion There was correlation between Angina pectoris of Coronary heart disease with Depression and Low T3 syndrome, Hcy and CRP. RT3, FT3 and CRP are risk factors of Angina pectoris of Coronary heart disease with Depression.
关键词	心绞痛；抑郁症；低T3综合征；HCY；CRP
KeyWord	Angina pectoris; Depression; Low T3 syndrome; Hcy ; CRP
基金项目
页码	1196-1200

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丁怀莹*,费玉玲,邵岩,张艳,哈永琴,王保和. 冠心病心绞痛合并抑郁症与低T3综合征、HCY及CRP的相关性 [J]. 国际精神病学杂志. 2020; 47; (6). 1196 - 1200.

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