双相障碍患者自杀相关因素分析

Analysis of suicide related factors in patients with bipolar disorder

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2020, 47(6)
作者
作者单位

济宁医学院 ;
济宁市精神病防治院 ;

摘要
目的:比较有和无自杀意念/行为的双相障碍(BD)患者的人口学资料和临床特征资料,分析双相障碍患者自杀意念/行为的相关因素及主要危险因素。方法:依据ICD-10诊断标准连续入组2018年1月至2018年12月住院的有自杀意念/行为的双相障碍患者共543例,根据是否伴有自杀行为,将患者分为自杀组(n=242例)和非自杀组(n=301例),比较分析其人口学和临床特征资料,通过Logistic回归分析探讨双相障碍患者自杀行为的主要危险因素。结果:与无自杀组相比,自杀组双相障碍患者女性[139(57.40)vs.129(42.90),χ2=-3.375,P=0.001]、既往发作次数、首发抑郁症状[189(78.10)vs.176(58.50),χ2=24.522,P=0.000]、有精神刺激[99(40.90)vs.88(29.20),χ2=14.496,P=0.000]、伴妄想性质的精神病性症状[138(65.40)vs.173(74.60),χ2=-2.267,P=0.023]差异有统计学意义( P值均< 0. 05) 。多因素Logistic 回归分析显示,女性(OR:1.79,95%CI:1.252~2.557)、首发抑郁症状(OR:2.288,95%CI:1.549~3.379)与双相障碍自杀风险因素相关( P均 < 0. 05) 。结论:女性、抑郁首发可能是双相障碍患者自杀意念/行为的独立危险因素,重点关注其危险因素对预防自杀有重要意义。
Abstract
Objective: To compare the demographic data and clinical character-istics of bipolar disorder (BD) patients with and without suicidal ideation/b-ehavior, and analyze the related factors and main risk factors of suicidal ide-ation/behavior in bipolar disorder patients.Methods: According to diagnostic c-riteria straight into the group of ICD - 10 January 2018 to December 2018 in t-he hospital have suicidal thoughts/behavior, a total of 543 patients with bipo-lar disorder, according to whether with suicidal behavior, divided the patients into suicide group (n = 242) and the suicide group (n = 301), the comparative analysis of the demographic and clinical characteristics of the data, by Logis-tic regression analysis on patients with bipolar disorder a major risk factor for suicidal behavior.Results:Compared with the non-suicidal group, the majori-ty of women in the suicidal group had bipolar disorder [139 (57.40) vs.129(42.90), χ2=-3.375, P=0.001], previous episodes, first depressive symptoms [189 (78.10) vs.176 (58.50), χ2=24.522, P=0.000], mental stimulation [99 (40.90) vs.88 (29.20), χ2=14.496,P=0.000], psychiatric symptoms with delusional nature [138 (65.40) vs.173 (74.60), χ2=-2.267,P=0.023] were statistically significant (all P values were < 0.05).Multivariate Logistic regression analysis showed th-at in females (OR: 1.79, 95%CI: 1.252~2.557), first depressive symptoms (OR: 2.288, 95%CI: 1.549~3.379), and psychotic symptoms with delusion (OR: 1.551, 95%CI: 1.03~2.336) were associated with suicide risk factors for bipolar disorder (all P < 0.05).Conclusion: Female,depressive episode may be independent risk f-actors for suicidal ideation/behavior in patients with bipolar disorder.
关键词
双相情感障碍;自杀;自杀行为;自杀观念;临床特征
KeyWord
Bipolar disorder; Suicide; Suicidal behavior; Suicidal thoughts; Clinical characteristics
基金项目
页码 1148-1152
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杨蕾,王中刚,张云,胡丹丹,张金响*. 双相障碍患者自杀相关因素分析 [J]. 国际精神病学杂志. 2020; 47; (6). 1148 - 1152.

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