| Abstract |
【Abstract】 Objective To investigate the incidence of abnormal lipid metabolism of hospitalized schizophrenia inpatients and relative factors. Methods A self-made questionnaire was used to investigate the 235 hospitalized schizophrenia inpatients. Gender, age, educated years, course of disease, hospital stays, past medical history (hypertension, diabetes), and use of antipsychotic drugs were collected. Meanwhile, body mass, height, blood glucose, triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein were measured. Results Among 235 hospitalized schizophrenia inpatients, 158（67.2%）cases of which were complicated with abnormal lipid metabolism. Extraverted, overweight, hypertensive and non-aripiprazole patients were more likely to have abnormal lipid metabolism (P < 0.05).Total cholesterol and triglyceride in extraverted patients were significantly higher than that in introverted patients (P < 0.05).Triglyceride in overweight patients was significantly higher than that in non-overweight patients (P < 0.01).Triglycerides were significantly higher in hypertensive inpatients with schizophrenia than in non-hypertensive patients (P < 0.05).There were no statistically significant differences in total cholesterol, triglyceride, high-density lipoprotein or low-density lipoprotein between hospitalized schizophrenic patients taking aripiprazole and those not taking aripiprazole (P > 0.05).Logistic regression analysis showed that extraversion and overweight were high risk factors for abnormal lipid metabolism, while aripiprazole was a protective factor for abnormal lipid metabolism. Conclusions The incidence of abnormal lipid metabolism was higher in hospitalized schizophrenics. Extroverted, overweight patients are more prone to abnormal lipid metabolism, and aripiprazole can reduce the risk of lipid metabolism abnormalities.
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