抗焦虑抑郁辅助治疗对慢性阻塞性肺疾病患者不良心理状态的影响
Effect of adjuvant anti-anxiety and depression therapy on adverse mental state of patients with chronic obstructive pulmonary disease
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2021, 48(1) |
| 作者 |
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| 作者单位 |
河南省新郑市中医院 ;
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| 摘要 |
【摘要】目的：探究抗焦虑抑郁辅助治疗对慢性阻塞性肺疾病（COPD）患者的抗焦虑抑郁水平及肺功能的影响。方法：回顾性选取我院2017年6月至2019年10月期间129例COPD患者作为研究对象，根据治疗方案不同分为对照组和观察组。对照组给予常规治疗，观察组增加米氮平治疗，4周末观察两组患者临床疗效、焦虑抑郁程度、肺功能及生活质量。结果：观察组临床总有效率92.31%高于对照组67.19%（P<0.05）。两组患者4周末HAMD、HAMA水平均降低，且观察组低于对照组（P<0.05）。两组患者FVC、FEV1、FEV1/FVC水平均升高，且观察组高于对照组（P<0.05）。观察组4周末躯体功能、心理功能、认知功能、社会功能及总体功能水平低于对照组（P<0.05）。结论：抗焦虑抑郁辅助治疗可通过拮抗α2受体和5-HT受体以改善COPD患者的抑郁焦虑情绪，缓解呼吸困难，调节肺功能水平，改善生活质量，提高临床疗效。
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| Abstract |
[Abstract] Objective: To explore the effect of anti-anxiety and depression adjuvant therapy on the level of anti-anxiety and depression and lung function in patients with chronic obstructive pulmonary disease (COPD). Methods: Retrospectively selected 129 patients with COPD from June 2017 to October 2019 in our hospital as the research object, and were divided into a control group and an observation group according to different treatment schemes. The control group was given conventional treatment, and the observation group was treated with mirtazapine. The clinical efficacy, degree of anxiety and depression, lung function and quality of life of the two groups were observed over the weekend. Results: The total clinical effective rate of the observation group was 92.31% higher than that of the control group 67.19% (P<0.05). The levels of HAMD and HAMA decreased in the two groups at the weekend, and the observation group was lower than the control group (P<0.05). The levels of FVC, FEV1, FEV1/FVC increased in both groups, and the observation group was higher than the control group (P<0.05). The body function, psychological function, cognitive function, social function and overall function level of the observation group at the weekend were lower than those of the control group (P<0.05). Conclusion: Anti-anxiety and depression adjuvant therapy can improve the depression and anxiety of COPD patients by antagonizing α2 receptors and 5-HT receptors, ease breathing difficulties, adjust lung function levels, improve quality of life, and improve clinical efficacy.
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| 关键词 |
【关键词】抗焦虑抑郁辅助治疗; 慢性阻塞性肺疾病; 不良心理状态
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| KeyWord |
[Keywords] adjuvant anti-anxiety therapy; chronic obstructive pulmonary disease; unhealthy mental state
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| 基金项目 |
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| 页码 |
142-144 |
郭静*.
抗焦虑抑郁辅助治疗对慢性阻塞性肺疾病患者不良心理状态的影响 [J].
国际精神病学杂志.
2021; 48; (1).
142 - 144.