| Abstract |
［Abstract］ Objective To study the difference of cerebral blood flow perfusion parameters in patients with Parkinsons disease and Parkinsons disease with depression. Methods 76 patients with Parkinsons disease and depression in our hospital were selected as the observation group, who were treated with high frequency repetitive transcranial magnetic stimulation (rTMS) for 4 weeks;In addition, 88 patients with Parkinsons disease who were admitted to the hospital during the same period were selected as the control group, and did not receive high-frequency rTMS treatment.The 17 Hamilton Depression Scale (HAMD-17) was used to evaluate the HAMD-17 scores of the observation group before and after treatment, and the CEREBRAL blood flow (CBF) of the observation group before and after treatment was compared with that of the control group in bilateral frontal lobe, parietal lobe, temporal lobe and basal joint region.Results Before treatment, CBF of bilateral frontal lobe, parietal lobe, temporal lobe and basal ganglia of the observation group was significantly lower than that of the control group (P<0.05), and CBF of left parietal lobe and frontal lobe was significantly lower than that of right side (P<0.05);After treatment, CBF of bilateral frontal lobe, parietal lobe, temporal lobe and basal ganglia in the observation group was significantly higher than that before treatment (P<0.05), but CBF of bilateral temporal lobe, basal ganglia and left parietal lobe was significantly lower than that in the control group (P<0.05).The HAMD-17 scores of patients with Parkinsons disease combined with depression were significantly lower after treatment than before (P<0.05).Conclusion Patients with Parkinsons disease have focal decreased cerebral blood flow perfusion, while patients with depression have more prominent decreased cerebral blood flow in frontal lobe, parietal lobe and other brain areas, which can be improved by high-frequency rTMS treatment.
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