International Journal of Clinical Research

Objective To observe the clinical effect of levofloxacin treatment in patients with Helicobacter pylori (Hp) positive and chronic gastritis. Methods This study will adopt a randomized controlled trial design. A total of 82 patients with Hp positive and chronic gastritis (all treated at the university hospital from February 2023 to August 2024) were randomly selected and divided into two groups at a ratio of 1:1, namely the control group and the observation group, with 41 cases in each group. The control group received conventional quadruple therapy, while the observation group was treated with levofloxacin on this basis. The therapeutic effects and the incidence of adverse reactions in both groups were compared and analyzed to provide a scientific basis for choosing a better treatment method in clinical practice. Results The therapeutic effect of the observation group was significantly better than that of the control group (P < 0.05). The Hp eradication rate in the observation group was significantly lower than that in the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). Conclusion Replacing clarithromycin with levofloxacin in the conventional quadruple therapy can improve the treatment efficiency and Hp eradication rate, while reducing the incidence of adverse reactions.

Levofloxacin; Hp positive; Chronic gastritis; Effect