International Journal of Clinical Research

Background Angong Niuhuang Pill (ANP), a traditional Chinese medicine, is widely used in clinical practice for its effects in clearing heat, detoxifying, calming convulsions, and restoring consciousness. It has shown potential as an adjunctive treatment for Vascular Dementia (VaD), particularly in cases involving large vessel disease. Objective To evaluate the clinical adjunctive effects of ANP combined with conventional therapy in patients with large vessel VaD, and to establish an evaluation model based on a multi-dimensional framework. Methods An evaluation index system was constructed based on five dimensions: individual patient differences, medication usage, treatment methods, lifestyle factors, and healthcare environment and support systems. The Analytic Hierarchy Process was applied to develop an evaluation model for assessing the clinical adjunctive effects of ANP combined with conventional therapy. Empirical analysis was conducted using patient data from a hospital in Taizhou, Zhejiang Province. Results The results demonstrated that ANP combined with conventional therapy has significant clinical adjunctive effects in patients with large vessel VaD. Conclusion The study highlights the potential of ANP as an effective adjunctive treatment for large vessel VaD when used in combination with conventional therapy. The proposed evaluation model provides a comprehensive framework for assessing treatment outcomes in this patient population.

Angong Niuhuang Pill; Routine treatment; Vascular VaD patients; Auxiliary effects