EME1介导AKT信号通路与结肠癌的关系研究进展-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

EME1介导AKT信号通路与结肠癌的关系研究进展

Research progress on the relationship between EME1-mediated AKT signaling pathway and colorectal cancer

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DOI	10.12208/j.ijcr.20250237
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2025, 9(5)
作者	罗可宛¹,刘博伦²,李珊珊²,黄子璇³,黄胜利²*,
作者单位	1 华北理工大学中医学院河北唐山,2 华北理工大学附属医院胃肠肿瘤外科河北唐山,3 华北理工大学临床医学院河北唐山
摘要	结肠癌是常见消化系统恶性肿瘤之一，其发病机制涉及多个过程，而DNA损伤修复便是其中之一。EME1基因是DNA损伤修复基因之一，其变异和缺失可增加肿瘤易感性，已报道与多种肿瘤相关。故抑制EME1 基因介导的DNA 损伤修复机制有可能提高肿瘤化疗的敏感性，为结肠癌临床诊治提供一个有效的分子标志物和治疗靶点。
Abstract	Colorectal cancer is one of the common malignant tumors of the digestive system, and its pathogenesis involves multiple processes, including DNA damage repair. The EME1 gene is one of the DNA damage repair genes; its mutations and deletions can increase tumor susceptibility and have been reported to be associated with various tumors. Therefore, inhibiting the DNA damage repair mechanism mediated by the EME1 gene may enhance the sensitivity of chemotherapy for tumors, providing an effective molecular marker and therapeutic target for clinical diagnosis and treatment of colorectal cancer.
关键词	EME1；AKT信号通路；结肠癌
KeyWord	EME1; AKT signaling pathway; Colorectal cancer
基金项目
页码	66-69

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引用本文

罗可宛,刘博伦,李珊珊,黄子璇,黄胜利*. EME1介导AKT信号通路与结肠癌的关系研究进展 [J]. 国际临床研究杂志. 2025; 9; (5). 66 - 69.

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