皮质肌动蛋白在肿瘤发生发展中的作用及其机制-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

皮质肌动蛋白在肿瘤发生发展中的作用及其机制

The role and mechanisms of cortactin in tumorigenesis and progression

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DOI	10.12208/j.ijcr.20250248
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2025, 9(5)
作者	李亚磊,赵恩宏*,
作者单位	承德医学院附属医院外三科河北承德
摘要	皮质肌动蛋白（Cortactin）通过结合Arp2/3复合体及丝状肌动蛋白（F-actin）调控细胞骨架动态，参与细胞迁移、侵袭和伪足形成。其在结肠直肠癌、膀胱癌和胰腺癌等中过表达的cortactin通过多种机制促进肿瘤发生发展：1）磷酸化修饰调节肌动蛋白重组；2）与Arp2/3复合体协同形成侵袭伪足；3）干扰钙黏蛋白介导的细胞黏附；4）诱导基质金属蛋白酶（MMPs）分泌以降解细胞外基质。Cortactin的表达与肿瘤恶性程度及不良预后密切相关，提示其作为潜在治疗靶点的价值。然而，其在肿瘤发生中的具体因果机制仍需进一步阐明。
Abstract	Cortactin drives cancer progression by modulating cytoskeletal dynamics. It activates Arp2/3 to nucleate branched actin networks, facilitating invasive protrusions and cell migration. Overexpressed in colorectal, bladder, and pancreatic cancers, cortactin promotes development via multiple mechanisms: 1) phosphorylation-dependent actin remodeling; 2) disruption of E-cadherin-mediated cell-cell adhesion; 3) activation of FAK-Rac1 and MAPK pathways to enhance proliferation; and 4) upregulating MMPs to degrade extracellular matrix. Its overexpression correlates with aggressive tumor behavior and poor patient outcomes, underscoring its therapeutic potential. However, whether cortactin directly initiates tumorigenesis or amplifies existing oncogenic signals remains unclear, necessitating deeper mechanistic studies to establish causality and refine targeting strategies.
关键词	皮质肌动蛋白；恶性肿瘤；肿瘤侵袭
KeyWord	Cortactin; Malignant tumor; Tumor invasion
基金项目
页码	111-114

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引用本文

李亚磊,赵恩宏*. 皮质肌动蛋白在肿瘤发生发展中的作用及其机制 [J]. 国际临床研究杂志. 2025; 9; (5). 111 - 114.

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