骨髓移植后DNA分型变化对亲子鉴定结果的影响
The impact of DNA typing changes after bone marrow transplantation on paternity test results
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| DOI |
10.12208/j.ijcr.20250308 |
| 刊名 |
International Journal of Clinical Research
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| 年，卷(期) |
2025, 9(6) |
| 作者 |
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| 作者单位 |
海南祥正司法鉴定服务有限公司 海南三亚
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| 摘要 |
骨髓移植（即造血干细胞移植，HSCT）是治疗白血病、再生障碍性贫血等血液系统疾病的重要手段。然而，移植后供体造血干细胞在受体内重建血液系统的同时，会导致受体外周血DNA分型发生显著改变，形成“供体型”或“嵌合型”基因分型。这一现象对法医学个体识别及亲子鉴定提出了挑战，因此本文主要探讨骨髓移植后不同组织DNA分型变化规律及其对亲子鉴定的影响并提出科学应对策略。
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| Abstract |
Bone marrow transplantation (HSCT) is a crucial method for treating hematological disorders such as leukemia and aplastic anemia. However, after transplantation, the donors hematopoietic stem cells can lead to significant changes in the recipients peripheral blood DNA profile, resulting in a donor-type or chimeric genetic profile. This phenomenon poses challenges to forensic individual identification and paternity testing. Therefore, this article explores the patterns of DNA profile changes in different tissues following bone marrow transplantation and their impact on paternity testing, and proposes scientific strategies to address these issues.
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| 关键词 |
骨髓移植；DNA分型变化；亲子鉴定；鉴定结果；影响
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| KeyWord |
Bone marrow transplantation; DNA typing change; Paternity test; Identification results; Influence
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| 基金项目 |
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| 页码 |
146-148 |
刘素艳*.
骨髓移植后DNA分型变化对亲子鉴定结果的影响 [J].
国际临床研究杂志.
2025; 9; (6).
146 - 148.