G蛋白偶联受体靶向性纳米抗体研究进展
Research progress on G protein coupled receptor targeted nanobodies
ES评分 0
| DOI |
10.12208/j.ijcr.20250384 |
| 刊名 |
International Journal of Clinical Research
|
| 年，卷(期) |
2025, 9(8) |
| 作者 |
|
| 作者单位 |
生物岛实验室 广东广州
|
| 摘要 |
纳米抗体是来源于骆驼科动物重链抗体的单域抗体，具有体积小、结构稳定、易于工程化等特点。近年来，纳米抗体在靶向G蛋白偶联受体（GPCR）研究中展现出巨大潜力。本文综述了靶向GPCR的纳米抗体的筛选策略，探讨其在结构生物学与药物开发中的应用，并分析了当前的技术瓶颈与未来发展趋势，为相关研究和临床转化提供参考。
|
| Abstract |
Nanoantibodies are single domain antibodies derived from heavy chain antibodies of camelids, characterized by small size, stable structure, and ease of engineering. In recent years, nanobodies have shown great potential in targeting G protein coupled receptors (GPCRs). This article reviews the screening strategies for nanobodies targeting GPCRs, explores their applications in structural biology and drug development, and analyzes current technological bottlenecks and future development trends, providing references for related research and clinical translation.
|
| 关键词 |
G蛋白偶联受体；GPCR；纳米抗体
|
| KeyWord |
G protein coupled receptor; GPCR; Nano antibody
|
| 基金项目 |
|
| 页码 |
81-83 |
李菁,范治然,张胜蓝*.
G蛋白偶联受体靶向性纳米抗体研究进展 [J].
国际临床研究杂志.
2025; 9; (8).
81 - 83.