Journal of International Psychiatry

【Abstract】Objective To explore the effect of olanzapine combined with insomnia intervention on the sleep quality and mental state of patients with coronary heart disease and hypertension. Methods A total of 100 patients with coronary heart disease and hypertension in our hospital from October 2017 to December 2019 were selected and grouped according to the random number table method. 50 cases in the control group were given insomnia intervention, and 50 cases in the observation group were treated with olanzapine on this basis. Sleep quality was compared after 2 months: assessed by Pittsburgh Sleep Quality Index (PSQI); mental state: self-rated depression Assessment by the Self-rating Anxiety Scale (SDS) and Anxiety Scale (SAS); the incidence of cardiovascular events. Results: After treatment, the PSQI scores and total scores, SDS, and SAS scores of the observation group were lower than those of the control group, with statistical significance (P<0.05). The incidence of cardiovascular events in the observation group was 6.00% lower than that in the control group 28.00%, which was statistically significant (P<0.05). Conclusion: Olanzapine combined with insomnia intervention in the treatment of patients with coronary heart disease and hypertension can improve sleep quality and reduce the incidence of anxiety, depression and cardiovascular events.

[Keywords] Olanzapine; Insomnia intervention; Coronary heart disease; Hypertension