International Journal of Clinical Research

Objective To explore the study of silk fibroin gel dressings in the treatment of high-risk human papillomavirus infection complicated with gynecological inflammation. Methods A total of 150 patients with high-risk human papillomavirus infection complicated with gynecological inflammation who were admitted to our hospital from January 2024 to December 2024 were selected and randomly divided into the control group (75 cases, treated with lactic acid bacteria vaginal capsules) and the experimental group (75 cases, treated with silk fibroin gel dressings). The clinical therapeutic effects, levels of inflammatory factors, HPV negative conversion status and vaginal microecological conditions (vaginal pH value, Nugent score) of the two groups were compared and evaluated. Results The levels of various inflammatory factors in the experimental group were all lower than those in the control group (P < 0.05). The vaginal pH value and Nugent score of the patients in the experimental group were both lower than those in the control group (P < 0.05). The HPV negative conversion rate and the effective rate of clinical treatment in the experimental group were both higher than those in the control group (P < 0.05). Conclusion The application of silk fibroin gel dressings in the treatment of patients with high-risk human papillomavirus infection complicated with gynecological inflammation has achieved remarkable results. It can significantly increase the HPV negative conversion rate of patients, reduce inflammatory responses, improve vaginal microecology, and has high clinical application value.

High-risk human papillomavirus infection; Silk fibroin gel dressing; Gynecological inflammation; Therapeutic effect