| Abstract |
[Abstract] Objective To analyze the effect of dexmedetomidine combined with remifentanil for sedation and analgesia and the incidence of delirium in mechanically ventilated patients in the intensive care unit (ICU). Methods According to the coin toss method, 81 mechanically ventilated ICU patients in our hospital were divided into 41 cases in the dexmedetomidine group and 40 cases in the midazolam group. Patients in the midazolam group were treated with fentanyl and midazolam for sedation Patients in the dexmedetomidine group were treated with remifentanil combined with dexmedetomidine for sedation and analgesia. The pain and sedative effects, changes in stress response, respiratory mechanics index levels, delirium, restlessness, and human-machine confrontation were compared between the two groups Incidence rate. Results The RASS scores of the two groups of patients after sedation were not statistically significant (P>0.05). The NRS scores of the dexmedetomidine group were lower than those of the midazolam group at 24h, 48h, 72h, and 96h after sedation (P<0.05); The levels of NE, Cor, Ptp-ei, △Ptp and the incidence of restlessness, delirium, and human-machine confrontation in the dexmedetomidine group were lower than those in the midazolam group, and the Ptp-ee level was higher than that in the midazolam group (P< 0.05). Conclusion Dexmedetomidine combined with remifentanil has better analgesia and sedation in ICU mechanically ventilated patients, which can significantly inhibit the bodys stress response, reduce the impact on respiratory function, and reduce restlessness, human-machine confrontation and delirium rate.
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